Search results for "node"

Biotech companies with little to no revenue can still be worth billions. Consider the most prominent 2017 biotech M&A deal when Gilead bought Kite Pharma for almost $12 billion. At the time of the deal, Kite had over $600 million in accumulated deficit, but it also had a pipeline of CAR-T cell therapies, which treat cancer. This article examines how to value such pipelines. It also focuses on the risk-adjusted NPV valuation methodology, portfolios of multiple drug candidates, and how value is impacted by the characteristics of the investor or acquirer.

React.js is a fantastic library. It is only one part of a front-end application stack, however. It doesn’t have much to offer when it comes to managing data and state. Facebook, the makers of React, have offered some guidance there in the form of Flux. I’ll introduce basic Flux control flow, discuss what’s missing for Stores, and how to use Backbone Models and Collections to fill the gap in a “Flux-compliant” way.

Several factors conspired to stifle Android Wear growth, ranging from lack of Google development, to inadequate hardware. Some of these problems have been addressed, some are being addressed, while others cannot be addressed with currently available technology.

Despite initial skepticism, React Native is very much in demand today!

In this article, Toptal Freelance React Native Developer, and former React Native skeptic, Alexander Pataridze talks about why he became a React Native advocate instead and introduces us to the technology by illustrating four use-cases.

Consistent Hashing is a distributed hashing scheme that operates independently of the number of servers or objects in a distributed hash table. It powers many high-traffic dynamic websites and web applications.

In this tutorial, Toptal Freelance Software Engineer Juan Pablo Carzolio will walk us through what it is and how hashing, distributed hashing and consistent hashing work.

When using a JavaScript framework, your browser doesn’t receive a complete page to display. Instead it gets a bunch of pieces and instructions of how to put them all together. It takes a substantial amount of time to put all this information together before your browser actually has something to display.

In this article, Toptal Freelance Front-end Engineer Ben Jones introduces us to Nuxt.js, a server-side rendering library for Vue.js, inspired by the popular Next.js for React.js.

Two heads are better than one. This proverb describes the concept behind ensemble methods in machine learning. Let’s examine why ensembles dominate ML competitions and what makes them so powerful.

Revenue-based financing allows an entrepreneur to repay an investment over time, to retake ownership of their business, and give a capped return to investors. With founders increasingly rejecting the scale-at-all-costs mentality, this article investigates the math of revenue-based investing and whether in VC it is possible to play averages over home runs.

The microservices architectural pattern is an architectural style that is growing in popularity, given its flexibility and resilience.

In this article, Toptal Freelance Python Developer Guilherme Caminha will focus on building a proof of concept microservices application in Python using Nameko, a microservices framework.

JavaScript and Redux expert Erik Rasmussen discusses the challenges of open-source software development, the fluctuating world of JavaScript, how he deals with imposter syndrome and burnout as an in-demand developer, and his top podcast recommendations.

In this tutorial, Toptal Freelance Software Engineer John R. Kosinski will demonstrate a simple Amazon Alexa hack using quintessential Arduino skills and basic hardware.